How salts in the brain make us wake up

man wears "wake up" glasses

Salts in the brain appear to play a bigger role that scientists previously thought in whether we are asleep or awake.

By influencing the level of salts, researchers were able to control a mouse’s sleep-wake cycle.

“The brain is more than a group of neurons that function like a computer.”

“The discovery reveals a completely new layer of understanding of how the brain functions,” says Professor Maiken Nedergaard from the Center for Basic and Translational Neuroscience at the University of Copenhagen.

“First and foremost, we learn more about how sleep is controlled. It may, however, also open up for a better future understanding of why some people suffer convulsive fits when staying awake all through the night.”

The researchers used mice to test whether injecting salt into the brain enables control of the mouse’s sleep-wake cycle—independently of the so-called neuromodulators. They report their results in Science.

Neuromodulators are compounds such as, for example, adrenalin, which plays a decisive role in our waking up every morning. The study shows that adrenalin and other neuromodulators change the level of salts surrounding the neurons, and that the salt balance then decides whether the neurons are sensitive to stimulation in the shape of a touch.

[Side sleeping may clean up the ‘mess’ in your brain]

When we are awake, the salt balance makes neurons highly sensitive to stimulation, as opposed to the salt balance in the brain during sleep, where the level of salts makes it harder to activate the neurons.

“It’s much simpler than previously believed in brain research. The research conducted used to focus only on the brain’s neural activity as a means of mapping and analyzing complicated processes such as being asleep or awake,” says Nedergaard. “Our study shows that the brain uses something as simple as changing the level of salts to control whether we are asleep or awake.

“This discovery reveals that studying only neurons in order to understand brain activity is not enough. We must include all the supportive cells, especially the so-called astrocytes, which regulate the level of salts in the brain. The brain is more than a group of neurons that function like a computer.

“The fact that the brain needs seven-to-eight hours of sleep to function well on a daily basis reveals that there’s much more we need to understand, aside from neurocomputation.”

Source: University of Copenhagen

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