Anyone who has received a local anesthesia and watched while a doctor operated on their leg or arm, you may remember a strange sensation: Your own body part seems foreign, as if it doesn’t belong to your body.
One reason for this is that the brain still knows which position the limb occupied before the local anesthetic took effect. As soon as it wears off, the spooky sensation disappears.
For people who have suffered a spinal cord injury or a stroke, however, this “estrangement” of their own limbs doesn’t go away, because an injury of this kind impairs or disrupts communication between the brain and the body. This affects the anatomical reconstruction of the body in the brain, known as body representation.
Our brain and our limbs constantly exchange data on position, orientation, and condition—somatosensory information. The eye is involved in body awareness as well.
The brain, for its part, processes this visual and somatosensory information to form an image of the body and “files” it in the cerebral cortex. Whether and to what extent damage to the spinal cord alters the body representation, however, is still a matter of dispute among experts and doctors.
Now researchers from a number of institutions have conducted a new study that sheds more light on the matter.
They used an established test to analyze whether and to what extent the body representation in paraplegics differs from that in healthy individuals.
During his research sabbatical at ETH Zurich, corresponding author Silvio Ionta (now lecturer at the University of Lausanne) developed a task in which participants were shown pictures of foreign body parts, such as a foot or a hand, or even of the entire body. While the images were being presented, the participants could not see their own hands and feet, but kept them either parallel to one another or in a crossed position.
The participants—22 patients with either a partial (11) or complete (11) severing of the spinal cord, and 16 control subjects with an intact spinal cord—were asked to determine which side of the body the body parts presented in the pictures belonged to.
The images were also shown in various orientations. Finally, the researchers measured the time it took from the presentation of the image until the subjects gave a verbal response.
“This test allows us to query, indirectly and objectively, whether and how the brain and limbs communicate with each other,” says Rogert Gassert, one of the leaders of the study and a professor at ETH Zurich.
Severity of the injury
The task was more difficult for participants whose spinal cord was completely severed. On the task with full body images, they took considerably longer—up to 50 percent more response time—than participants with partial and no spinal cord injury.
“The more severely the spinal cord is damaged, the longer the response time needed to assess pictures of the body, and the greater the alteration of the full-body representation in the brain,” says Gassert.
The brain subconsciously perceives the observer’s own current body position while looking at the pictures, and that this influences their assessment of the image, he explains. If the spinal cord is completely severed, the brain receives only visual stimuli.
“The body representation is thus distorted, and those affected have greater difficulty solving the assigned task,” says Gassert.
But the tests also helped the researchers to estimate how strongly the partial or complete paraplegia affects the representation of the body parts they showed. In all participants, hand representation was unchanged. When participants held their own hands crossed during the tests, a similar increase in response time was observed in all three groups.
The position of the feet, on the other hand, had a noticeable impact on response time, but only for participants whose spinal cord was entirely or only partially damaged. Those with complete paraplegia did not show the typical increase in response times that one would expect in healthy conditions.
Implications for rehabilitation?
This suggests that the brain in individuals with a complete severing of the spinal cord represents the foot differently than is the case with individuals whose brain still receives information from the lower extremities.
Participants with partial or complete paralysis are able to solve the tasks just as precisely and correctly as healthy subjects—this also suggests the representation in the brain is dynamic and adaptable.
According to Gassert, the study has implications for rehabilitation and therapy for people with paraplegia.
“This test can help hospital staff to objectively determine the extent to which the body representation in the brain has been altered,” he says.
But he can also see applying the findings to stimulate the brain networks responsible for body representation, thus keeping them active.
“This approach could help keep the body representation ‘awake’ even after a spinal cord injury. Going beyond that, it could serve to produce standardized mental commands and thus move an exoskeleton with a brain-computer interface,” says Gassert.
The study appears in Scientific Reports.
Source: ETH Zurich
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