The history of eczema in two words: bad luck

Sometimes the genes that cause disease can also benefit human health, but a closer look at the evolutionary history of eczema finds no such benefits.

It appears the itchy skin condition is a random vestige of evolution, says University at Buffalo biologist Omer Gokcumen, who led the research.

“We present a complex evolutionary history of this disease variant, and it seems to be just bad luck that it has endured for so long,” says Gokcumen, an assistant professor of biological sciences. “Unlike other disease variants, such as those linked to sickle cell anemia or psoriasis, the one we studied is just not that important from the standpoint of evolution.

“It doesn’t appear to affect what biologists call ‘fitness,’ which is another word for reproductive success.”

The research was based on a data set that included the genomes of more than 2,500 people around the world.

map of populations that carry the eczema gene
Pie charts show the proportion of chromosomes within different populations worldwide that carry a non-working copy of the filaggrin gene, a primary risk factor for eczema. (Credit: Duo “Erica” Xu/U. Buffalo)

The gene at the heart of the research is the filaggrin gene, which tells the body how to make a protein of the same name in skin cells.

In some people, inherited genetic mutations cause the filaggrin gene to stop working, impairing healthy skin function and creating an increased risk for developing eczema. The study found that “loss of function” mutations are significantly more common in filaggrin than in other human genes.

However, despite this prevalence, the variants don’t appear to serve an adaptive purpose: “The loss of function creates a susceptibility to eczema, but it does not appear to have an effect on the reproductive success of modern humans,” Gokcumen says.

People from East Asia

The scientists’ conclusions held true even when they took a closer look at the genomes of individuals from East Asia, who are more likely to have broken filaggrin genes than people from other parts of the world.

A genomic analysis showed that this trend may have been an artifact of evolutionary hitchhiking: In East Asia, many people share a genetic profile that includes a loss-of-function mutation for filaggrin, paired with a notable mutation in a nearby gene that carries instructions for making hornerin, another human protein.

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While the filaggrin mutation did not appear to have importance from the standpoint of evolution and adaptation, the hornerin mutation did. This leads Gokcumen to believe that the filaggrin mutation may have proliferated in East Asia for the sake of preserving the hornerin mutation.

As he explains, large sections of the genome are often lost or inherited together during evolution, so genes like those for hornerin and filaggrin that are close to each other often share an evolutionary history.

While the research did not draw concrete conclusions about why the hornerin mutation was so important, changes in the hornerin gene can affect healthy skin function, influencing microbiome diversity on the skin.

The research was a partnership between colleagues at Buffalo, the Northwestern University Feinberg School of Medicine, the University of Minnesota, and Pennsylvania State University. The team published their findings in the journal Genome Biology and Evolution.

Source: University at Buffalo

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