Exercise, not diet, changed gut microbes in rats

rats on an exercise wheel

Metabolism and gut microbes are considered key players in the fight against obesity. However, there is an ongoing debate about whether exercise or diet is better at promoting metabolism and healthy shifts in gut microbes, the microscopic organisms in our intestines that break down food and contribute to decreased obesity.

“Some have claimed that exercise may not play a significant role in weight loss, as exercise can increase appetite resulting in greater food intake and potentially reduce activity throughout the day,” says Vicki Vieira-Potter, assistant professor of nutrition and exercise physiology at the University of Missouri.

“The purpose of this study was to look at exercise independently from weight loss and to determine other metabolic benefits associated with physical activity. Our team aimed to tease out what effects on adipose, or fat tissue, were due to weight loss from diet, and what could be attributed to exercise.”

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Researchers divided young rats prone to obesity into three groups to study the impact of exercise on their metabolic function and fat tissue. All three of the rat groups were fed a high-fat diet. Two of the groups were sedentary while the third group was able to exercise using running wheels.

Of the two sedentary groups, one was allowed to eat as much of the high-fat food as they wanted, while the other group were fed controlled portions of the food in order to match the weight reduction caused by exercise. The exercising rats were allowed to eat as much as they wanted.

Several weeks later, all the rats were moved to specialized cages where researchers could measure their metabolism and physical activity.  The rats with unlimited food access were obese, unlike the sedentary rats fed a reduced amount of the same diet and the rats that exercised, which was expected.

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But, researchers also found that the exercising rats were metabolically healthier than both of the sedentary groups, and they developed different gut microbes than the other groups, despite eating the exact same amount of food as the sedentary group with unlimited food access.

The findings are published in the journal Medicine and Science in Sports and Exercise.

“Overall, the exercising rats had higher metabolic rates, were more active even when not running on their wheels, and experienced shifts in their gut microbes, perhaps putting them in a better position to avoid future weight gain compared to the other groups,” Vieira-Potter says.

“These findings confirm that exercise is an important component of overall health and is critically important in the fight against obesity, especially during the juvenile period.”

Source: University of Missouri

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